Christian Seelos


My Publications

Cells treated with oxidized low-density lipoprotein activate a suicide mechanism (Apoptosis). Signs of Apoptosis include fragmentation of DNA in the cell’s nucleus (light areas). Seelos (1997).

Analytical model of the joint venture of Telenor and Grameen. We model business models to identify the key organizational mechanisms that generate desirable outcomes and drive achievement of strategic objectives. (Seelos 2007, 2014).

Exner, M., Hermann, M., Hofbauer, R., Kapiotis, S., Speiser, W., Held, I., Seelos, Ch. and Gmeiner, B.M. (2000) The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein. FEBS Lett. 470, 47-50

Hermann, M., Kapiotis, S., Hofbauer, R., Exner, M., Seelos, Ch., Held, I., Gmeiner, B. (1999) Salicylate inhibits LDL oxidation initiated by superoxide/nitric oxide radicals. FEBS Lett. 445, 212-214

Dallinger, G., Oberkofler, H., Seelos, Ch., Patsch, W. (1999) Transcriptional elongation of the rat apolipoprotein A-I gene: identification and mapping of two arrest sites and their signals. J. Lipid Res. 40, 1229-1239

Hermann, M., Kapiotis, S., Hofbauer, R., Seelos, Ch., Held, I., Gmeiner, B. (1999) Salicylate promotes myeloperoxidase-initiated LDL oxidation: Antagonization by its metabolite gentisic acid. Free Radical Biol. Med. 26, 1254-1260

Gerner, C., Seelos, Ch., Sauermann, G. (1998) Alteration of nuclear matrix protein composition during apoptosis in rat embryo cells. Exp. Cell. Res. 238, 472-480

Peck-Radosavljevic, M., Pidlich, J., Bergmann, M., Ferenci, P., Riegler-Keil, M., Seelos, Ch. et al. (1998) Preoperative TMM-classification is a better prognostic indicator for recurrence of hepatocellular carcinoma after liver transplantation than albumin mRNA in peripheral blood. J. Hepatol. 28, 497-503

Austen, M., Cerni, C., Henriksson, M., Hilfenhaus, S., Lüscher-Firzlaff, J. M., Menkel, A., Seelos, Ch., Sommer, A., Lüscher B. (1997) Regulation of cell growth by the Myc-Max-Mad network: Role of Mad proteins and YY1. Curr. Top. Microbiol. Immunol. 224, 123-130

Seelos, Ch., Gmeiner, B., Kapiotis, S., Cerni, Ch. (1997) Programmed death of endothelial cells triggered by oxidized low-density-lipoprotein. Biochem. Mol. Biol. Int. 42, 1015-1022

Kapiotis, S., Herrmann, M., Held, I., Seelos, Ch., Ehringer, H., Gmeiner, B. (1997) Genistein, the dietary-derived angiotensin inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Atheroscl. Thromb. Vasc. Biol. 17, 2868-2874

Kapiotis, S., Senguelge, G., Herrmann, M., Held, I., Seelos, Ch., Gmeiner, B. (1997) Paracetamol catalyzes myeloperoxidase-initiated lipid oxidation in LDL. Atheroscl. Thromb. Vasc. Biol. 17, 2855-2860

Seelos, Ch. (1997) A critical parameter determining the aging of DNA-calcium phosphate precipitates. Anal. Biochem. 245, 109-111

Gmeiner, B., Seelos, Ch. (1996) Tyrosine phosphorylation blocks tyrosine free radical formation and hence the hormonogenic iodination reaction. Free Radical Bio. Med. 21, 349-351

Cerni, Ch., Seelos, Ch. (1995) Papillomaviruses as promoting agents in human epithelial tumors. in: DNA Tumor Viruses: Oncogenic mechanisms. (Giuseppe Barbanti-Brodano et al., eds.), Plenum Press, New York, pp. 123-155

Gmeiner, B.M.K., Seelos, Ch. (1995) Modulation of biological tyrosine reactions by tyrosine phosphorylation. Wien. Klin. Wochenschr. 107, 687-689

Gmeiner, B., Seelos, Ch. (1995) Measurement of phosphotyrosine phosphatase activity using the Folin-Ciocalteu phenol reaction. Biochem. Mol. Biol. Int. 36, 943-948

Gmeiner, B., Leibl, H., Zerlauth, G., Seelos, Ch. (1995) Affinity binding of distinct functional fibronectin domains to immobilized metal chelates. Arch. Biochem. Biophys. 321, 40-47

Cerni, C., Bousset, K., Seelos, Ch., Burkhardt, H., Henriksson, M., Lüscher, B. (1995) Differential effects by Mad and Max on transformation by cellular and viral oncoproteins. Oncogene 11, 587-596

Soyal, S.M., Seelos, Ch., Lin-Lee, Y.C., Sanders, S., Gotto, A.M., Hachey, D.L., Patsch, W. (1995) Thyroid hormone influences the maturation of apolipoprotein A-I messenger RNA in rat liver. J. Biol. Chem. 270, 3996-4004

Seelos, Ch., Cerni, C. (1994) The addition of a nuclear matrix associated region promotes the biological effects of HPV11. Cell Biol. Int. 18, 388a

Gmeiner, B., Seelos, Ch. (1994) Nonreaction of phosphotyrosine with the Folin phenol reagent. Anal. Chem. 66, 917-918

Seelos, Ch., Gmeiner, B., Rainer, P., Marian, B. (1992) Dityrosine formation is impaired by tyrosine phosphorylation. Biochem. Biophys. Res. Comm. 188, 252-256

Radosavljevic, M., LinLee, Y.C., Soyal, S.M., Strobl, W., Seelos, Ch., Gotto, A.M., Patsch, W. (1992) Effect of sucrose diet on expression of apolipoprotein genes A-I, C-III and A-IV in rat liver. Atherosclerosis 95, 147-156

Jäger, W., Czejka, M., Seelos, Ch., Schüller, J., Fogl, U. (1991) Untersuchungen zur Zerfallskinetik von Ftorafur. Sci. Pharm. 59, 101-106

Goldenberg, H., Seelos, Ch., Chatwani, S., Chegini, S., Pumm, R. (1991) Uptake and endocytic pathway of transferrin and iron in perfused rat liver. Biochim. Biophys. Acta 1067, 145-152

Seelos, Ch., Hüttinger, M. (1990) Concerted response of low density lipoprotein receptor expression to ethinyl-estradiol or high-cholesterol diet in organs and white blood cells (WBC). Arteriosclerosis 10, 860a

Goldenberg, H., Seelos, Ch., Chegini, S., Chatwani, S. (1990) Endocytosis of transferrin and iron in perfused rat liver. Cell Biol. Int. Rep. 14, 242a

Gmeiner, B., Scheidel, H., Seelos, Ch., Vetterlein, M., Hüttinger, M., Zerlauth, G. (1990) Zinc ions increase tumor promoter binding to human lung fibroblasts but decrease tumor promoter-mediated fibronectin release. J. Cancer Res. Clin. Oncol. 116, 100a

Seelos, Ch. (1990) Cellular mechanisms regulating blood cholesterol levels. Effects of diet and hormones. Thesis, University of Vienna, Faculty of Natural Sciences.

Gmeiner, B., Seelos, Ch. (1989) Phosphorylation of tyrosine prevents dityrosine formation in vitro. FEBS Lett. 255, 395-397

Gmeiner, B.M.K., Seelos, Ch. (1989) Phosphatidylserine modulates calf intestine alkaline phosphatase activity towards low and high molecular weight substrate. Biochem. Int. 18, 767-773

Hüttinger, M., Gmeiner, B., Kraupp, M., Seelos, Ch., Kramar, R. (1989) Peroxisomal ß-oxidation and bile acid synthesis. J. Clin. Chem. Clin. Biochem. 27, 294-295

a) Journal Articles, Book Series, and selected Working Papers

(underlined= downloadable)

Mair, J., Seelos, C. (2021) Organizations, Social Problems, and System Change: Invigorating the Third Mandate of Organizational Research. Organization Theory October 2021. Available at

Seelos, C. (2021). Homelessness, A System Perspective. The Journey of Community Solutions. Stanford Digital Repository. Available at

Seelos, C. (2021). System perspectives will slow us down and

that's a good thing! Stanford Digital Repository. Available at

Seelos, Ch. (2019) Changing systems? Welcome to the slow movement. Stanford Social Innovation Review 18 (1), 40-47.

Seelos, Ch., Mair, J. (2018) Mastering System Change. Stanford Social Innovation Review 16 (4), 35-41.

Mair, J., Seelos, Ch. (2017) Water is power. Impact India 2, Spring 2017, 24-29.

Mair, J., Wolf, M., Seelos, Ch. (2016) Scaffolding: A Process of Transforming Patterns of Inequality in Small-Scale Societies. The Academy of Management Journal, 59 (6), 2021-2044.

Paper nominated amongst top 4 articles of 2016 by the Academy of Management Journal.

Seelos, Ch., Mair, J. (2016) When Innovation Goes Wrong. Stanford Social Innovation Review 14 (4), 27-33.

Sarker, A., Abed, S., Seelos, Ch. (2016) Lessons in Scaling and Failing: The challenges of scaling up programs aimed at empowering adolescent girls in Bangladesh and Uganda. Stanford Social Innovation Review 14 (2), Supplement, 14-15.

Seelos, Ch., Mair, J. (2014) Organizational Closure Competencies and Scaling: A Realist Approach to Theorizing Social Enterprise, in Jeremy Short (ed.) Social Entrepreneurship and Research Methods (Research Methodology in Strategy and Management, Volume 9), Emerald Group Publishing Limited, 147-188.

Seelos, Ch. (2014) Theorizing and Strategizing with Models: Generative Models of Social Enterprises. International Journal of Entrepreneurial Venturing 6(1), 6-21.

Seelos, Ch., Mair. J. (2013) Innovate and Scale: A Tough Balancing Act. Stanford Social Innovation Review 11(3), 12-14.

Seelos, Ch., Mair. J. (2012) Innovation is not the Holy Grail. Stanford Social Innovation Review 10, 44-49.

Seelos, Ch., Mair. J. (2012) What determines the capacity for continuous innovation in social sector organizations? PACS Report to the Rockefeller Foundation.

Seelos, Ch., Mair. J. (2012) Organizational Capacity for Continuous Innovation-Outline of a Research Agenda. PACS Report to the Rockefeller Foundation.

Seelos, Ch., Mair, J. (2011) Organizational Mechanisms of Inclusive Growth: A Critical Realist Perspective on Scaling. PACS Working Paper DI-0840-E (submitted).

Seelos, Ch., Mair, J., Battilana, J., Dacin, M.T, (2011) The embeddedness of social entrepreneurship: Understanding variation across geographic communities. Research in the Sociology of Organizations 33, 333-363.

Seelos, Ch. (2009) Waste Concern: A Multistakeholder Business Model Creating an Urban-Rural Symbiosis. IBWE Working Paper 05/2009.

Seelos, Ch. (2008) The unfinished business of economic development. Wanted: New Solutions. ICFAI Effective Executive (November), 32-35.

Seelos, Ch., Mair, J. (2007) Profitable business models and market creation in the context of deep poverty: A Strategic View. Academy of Management Perspectives 21, 49-63.

Paper won two international awards:

1.Best Paper for Practitioner Implications Award 2007 of the Strategic Management Society.

2.International Finance Corporation(IFC)/Financial Times (FT) 2008 Gold Price out of 750 submissions of the "private sector development" research essay competition.

Mair, J., Seelos, Ch. (2006) Digital Democracy. European Business Forum 26, 59-61.

Seelos, Ch., Mair, J. (2006) Social Entrepreneurs - The contribution of individual entrepreneurs to sustainable development. The ICFAI Journal for Entrepreneurship Development (March), 30-46.

Seelos, Ch., Mair, J. (2006) A strategic view on profitable business models and market creation in the context of deep poverty. IESE Working Paper.

Seelos, Ch., Mair, J. (2006) Sustainable development: how social entrepreneurs make it happen. IESE Working Paper.

Seelos, Ch., Mair, J. (2005) Social Entrepreneurship: Creating New Business Models to Serve the Poor. Business Horizons 48, 247-252.

Paper consistently ranked amongst “25 Hottest Articles” by Science Direct for this journal.

Seelos, Ch., Mair, J. (2005) Sustainable development, sustainable profits. European Business Forum 20, 49-53.

Mair, J., Seelos, Ch., Borwankar, A. (2005) Social entrepreneurial initiatives within the sustainable development landscape. International Journal of Entrepreneurship Education 2, 46-49.

Seelos, Ch., Mair, J. (2004) Social entrepreneurship. The contribution of individual entrepreneurs to sustainable development. IESE Working paper.

Seelos, Ch. (2004) Finding a path in the sustainability jungle - a framework for corporate action. IESE Working paper.

Mair, J., Seelos, Ch., Borwankar, A. (2004) Emprendedores socials y desarrollo sostenible. Iniciativa Emprendedoria 43, 7-13.

Seelos, Ch. (1999) Lessons from Iraq on bioweapons. Nature 398, 187-188.

b) Books and Book Chapters:

Radeke J., Mair J., Seelos C. (2019) Waste Concern: Fixing Market Failures. In: Lenssen G., Smith N. (eds) Managing Sustainable Business. Springer: Dordrecht, 561-578.

Seelos, Ch., Mair, J. (2017) Innovation and Scaling for Impact: How Effective Social Enterprises Do It. Stanford University Press, Stanford.

Seelos, Ch. (2009) New Models for the Future, in Managing in a Downturn: Leading Business Thinkers on How to Grow When Markets Don't, FT Prentice Hall, 133-137.

Seelos, Ch. (2009) De toekomst is aan het symbiotische model, in Solman, P. Mattu, R. (eds.) Mastering Management in crisistijd, Nederlandstalig.  

Seelos, Ch., Mair, J. (2009) Hope for Sustainable Development: How Social Entrepreneurs Make it Happen, in Ziegler, R. (ed.) An Introduction to Social Entrepreneurship: Voices, Preconditions and Contexts, Cheltenham: Edward Elgar, 228-245.

Seelos, Ch. (2008) The social responsibility of corporations is innovation, in Business and Poverty, Innovative Strategies for Global CSR, Vienna: ICEP/CODESPA, 65-69.

Seelos, Ch., Mair, J. (2007) How social entrepreneurs enable human, social, and economic development, in Rangan, V., Quelch, J., Herrero, G., and Barton, B. (eds.) Business Solutions for the Global Poor: Creating Social and Economic Value, San Francisco: Jossey-Bass, 271-278.

Seelos, Ch., Mair, J. (2006) The Sekem Initiative, in Improving Management. A Selection of the best Cases from IESE Business School (IESE), 269-297.

Mair, J., Seelos, Ch. (2006) The Sekem Initiative: a holistic vision to develop people, in F. Perrini (ed.) New Social Entrepreneurship: What awaits social entrepreneurship ventures? Edgar Elgar: Cheltenham, 210-223.

Seelos, Ch., Ganly, K., Mair, J. (2006) Social entrepreneurs directly contribute to global development goals, in Mair, J., Robinson, J., and Hockerts, K. (eds.) Social Entrepreneurship, Palgrave Macmillan.

c) Case Studies:

Varley, P., Seelos, Ch. (2018) Transforming Desert Land & Human Potential: Egypt’s ‘SEKEM’ Initiative Reaches a Crossroads. Harvard Kennedy School.

Coudenhove-Kalergi, B., Seelos, Ch. (2012) EVN in Bulgaria (C) – Making it work… . Stanford PACS.

Coudenhove-Kalergi, B., Seelos, Ch. (2012) EVN in Bulgaria (B) – Engaging the Roma Community. Stanford PACS.

Seelos, Ch. (2011) EVN in Bulgaria - Eastern Phantasy Meets Eastern Reality. Case study. IESE Business School.

Seelos, Ch., Mair, J. (2007) Sekem – Liberating a Vision. An Artistic Approach to Entrepreneurship. Case study. IESE Business School.

Thurner, C., Seelos, Ch., Mair, J. (2006) Wasteconcern. IESE Study 33.

Seelos, Ch., Mair, J. (2006) BRAC: An enabling structure for social and economic development. IESE Study 34.

Seelos, Ch., Mair, J. (2004) Sekem - holistic development in the economic, cultural, and social spheres. Case study. IESE Business

d) Selected Newspaper Articles:

Seelos, Ch., May, M. (2015) Does the Development Sector Need Its Own WikiLeaks? Could radical transparency in global development lead to better outcomes? Stanford Social Innovation Review

Seelos, Ch. (2014) The Grammar of Poverty: A diagnostic framework for shaping innovation and scaling strategies. Stanford Social Innovation Review

Seelos, Ch., Mair, J. (2013) The Role of Research in Social Innovation Are research and practice two coins or two sides of the same coin? Stanford Social Innovation Review

Seelos, Ch. (2010) El estrés del agua: las nuevas dimensiones de riesgo empresarial. Portafolio (Colombia) 1 Nov 2010.

Seelos, Ch. (2009) Managing in a downturn: New models for the future. Financial Times, Feb 13.  

Seelos, Ch. (2008) Company lessons in reaching the world’s poorest*. Financial Times, March 17 (*winning article of an essay competition sponsored by the Financial Times and the International Finance Corporation on the private sector's role in development).

Seelos, Ch. (2005) Social Entrepreneurs. Wirtschaftsblatt/CorporAID (October), 52.

Seelos, Ch. (2004) Strategisches Soziales Engagement. Wirtschaftsblatt/CorporAID 3-1, 70.


Seelos, Ch., Mair, J. (2003) Entropy International - Enabling businesses to make a contribution to sustainable development. Case study. IESE Business School.

I. Natural Sciences

II. Social Sciences

New white paper on system change (Nov 2019)